Applied Biopharmaceutics and Pharmacokinetics, Seventh Edition

Description:

 

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  1. Explains how to detect clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them
  
  
  
  

 

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   1. Helps you critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency
   
   
   
   

 

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   1. Chapters have been revised to reflect the latest clinical perspectives on drug performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy
   
   
   
   

 

 

 

The field’s leading text for more than three decades, Applied Biopharmaceutics & Pharmacokinetics gets you up to speed on the basics of the discipline like no other resource. Practical problems and clinical examples with discussions are integrated within each chapter to help you apply principles to patient care and drug consultation situations. In addition, outstanding pedagogy, including chapter objectives, chapter summaries, and FAQs, plus additional application questions, identify and focus on key concepts.

 

 

1. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics shows you how to use raw data and formulate the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination. The book also helps you work with pharmacokinetic and biopharmaceutic parameters to design and evaluate dosage regimens of drugs. In the seventh edition of this must-have interactive learning tool, most of the chapters are updated to reflect our current understanding of complex issues associated with safe and efficacious drug therapy.
   Book Contents;


2. Chapter 1: Introduction to Biopharmaceutics and Pharmacokinetics
   


3. Chapter 2: Mathematical Fundamentals in Pharmacokinetics
   


4. Chapter 3: Biostatistics
   


5. Chapter 4: One-Compartment Open Model: Intravenous Bolus Administration
   


6. Chapter 5: Multicompartment Models: Intravenous Bolus Administration
   


7. Chapter 6: Intravenous Infusion
   


8. Chapter 7: Drug Elimination, Clearance, and Renal Clearance
   


9. Chapter 8: Pharmacokinetics of Oral Absorption
   


10. Chapter 9: Multiple-Dosage Regimens
    


11. Chapter 10: Nonlinear Pharmacokinetics
    


12. Chapter 11: Physiologic Drug Distribution and Protein Binding
    


13. Chapter 12: Drug Elimination and Hepatic Clearance
    


14. Chapter 13: Pharmacogenetics and Drug Metabolism
    


15. Chapter 14: Physiologic Factors Related to Drug Absorption
    


16. Chapter 15: Biopharmaceutic Considerations in Drug Product Design and In Vitro Drug Product Performance
    


17. Chapter 16: Drug Product Performance, In Vivo: Bioavailability and Bioequivalence
    


18. Chapter 17: Biopharmaceutical Aspects of the Active Pharmaceutical Ingredient and Pharmaceutical Equivalence
    


19. Chapter 18: Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy
    


20. Chapter 19: Modified-Release Drug Products and Drug Devices
    


21. Chapter 20: Targeted Drug Delivery Systems and Biotechnological Products
    


22. Chapter 21: Relationship Between Pharmacokinetics and Pharmacodynamics
    


23. Chapter 22: Application of Pharmacokinetics to Clinical Situations
    


24. Chapter 23: Application of Pharmaco­kinetics to Specific Populations: Geriatric, Obese, and Pediatric Patients
    


25. Chapter 24: Dose Adjustment in Renal and Hepatic Disease
    


26. Chapter 25: Empirical Models, Mechanistic Models, Statistical Moments, and Non-compartmental Analysis
    


27. Appendix A: Applications of Software Packages in Pharma-cokinetics
    


28. Appendix B: Glossary
    
    
    
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